Review paper on the use of high-dose estrogens (HDE) for the treatment of breast cancer

Review paper on the use of high-dose estrogens (HDE) for the treatment of breast cancer

Estrogens are known to stimulate the growth of breast cancer, whereas on the other hand estrogens are an effective treatment for this disease. The fact that estrogens can effectively be used for the treatment of breast cancer is something that almost has been forgotten about, whereas the fear for estrogens remains. This paper reviews the use of estrogens for the treatment of breast cancer and identifies possible applications for the future.

Coelingh Bennink et al Maturitas 2017 (HDE paper)

Results Dose-Escalating Study With the Fetal Estrogen Estetrol in Healthy Men published in The Journal of Clinical Endocrinology & Metabolism

Luteinizing hormone–releasing hormone agonists have replaced estrogens for endocrine treatment of advanced prostate cancer (PC) because of cardiovascular side effects. The published study with the fetal estrogen estetrol (E4) in healthy males shows promise as a safe and effective drug for use in prostate cancer.

A Dose-Escalating Study With the Fetal Estrogen JCEM 2018

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